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Antigenic proteins in latex products can cause type I allergy. We investigated the effects of potassium hydroxide (KOH) solution on the allergenicity of proteins in natural latex sap and latex gloves by using an EAST competitive inhibition immunoassay and skin prick test. Latex sap was mixed with KOH solution at different concentrations and incubated over various periods of time at room temperature.
Latex gloves were washed in KOH solution for different times at 30 degrees C and 90 degrees C. Our immunoassay results for the subsequently extracted latex proteins demonstrated a KOH concentration-, temperature-, and time-dependent decrease in allergenicity, finally resulting in complete loss of IgE-binding activity.
In the skin prick test, we found only four weakly positive reactions to proteins extracted from KOH-washed gloves in 30 latex-sensitized patients. In addition, up to 97% of the aqueous extractable protein content could be removed from latex gloves by washing in KOH solution under certain conditions. These results suggest that antigenic proteins in natural latex sap and latex gloves can be changed by treatment with KOH solution, which is followed by a loss of their capability to bind specific IgE antibodies from most latex-sensitized patients.
The SJG-2083CS Online Potassium hydroxide(KOH) concentration Meter is a brand-new online smart digital acid and alkali concentration meter with a digital inductive conductivity sensor and independently developed and manufactured by BOQU Instrument.
1.Extremely quickly and precision Acid-base concentration sensor.
2.It's suitable for harsh application and free maintenance, save cost.
3.Two ways of 4-20mA output for Acid-base concentration and temperature.
4.Digital Inductive conductivity sensor, precision for harsh application.
5.With the data recording function, users easy to check historical data and history curves.
HCl,Hydrochloric acid concentration:0.00%~17.98% ;20.01%~39.07%
NHO3,Nitric acid concentration:0.00%~30.00%
NaOH,Sodium hydroxide concentration:0.00%~25.99% ;15.13%~50.00%
H2SO4,sulfuric acid concentration:0.00%~30.25% ; 91.91%~100.00%
KOH,Potassium hydroxide concentration:0~26.00%,26~42.00%
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